Penn State Nittany Lions
| Date | Matchup | Result |
|---|---|---|
| 2025-08-30 | @  Nevada | 11-46 W |
| 2025-09-06 | @  Florida International | 0-34 W |
| 2025-09-13 | @  Villanova | 6-52 W |
| 2025-09-27 | @  Oregon | 30-24 L |
| 2025-10-04 | vs  UCLA | 37-42 L |
| 2025-10-11 | @  Northwestern | 22-21 L |
| 2025-10-18 | vs  Iowa | 24-25 L |
| 2025-11-01 | @  Ohio State | 38-14 L |
| 2025-11-08 | vs  Indiana | 24-27 L |
| 2025-11-15 | @  Michigan State | 10-28 W |
| 2025-11-23 | vs  Nebraska | 37-10 W |
| 2025-11-29 | @  Rutgers | 36-40 W |
| 2025-12-27 | @  Clemson | 10-22 W |
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